&Model &width 36 &height 1 &numsides 6 &Network Trap &Genes &X //turns on dpp & tld &Location cyto &Type protein &Color white &Show off &endX &Y //turns on tsg &Location cyto &Type protein &Color white &Show off &endY &Z //turns on sog &Location cyto &Type protein &Color white &Show off &endZ &dpp &Location cyto &Type rna &Color red &Show off &enddpp &DPP &Location membrane &Type protein &Color red &Show on &endDPP &tsg &Location cyto &Type rna &Color blue &Show off &endtsg &TSG &Location membrane &Type protein &Color blue &Show on &endTSG &sog &Location cyto &Type rna &Color cyan &Show off &endsog &SOG &Location membrane &Type protein &Color cyan &Show on &endSOG &SUP &Location membrane &Type protein &Color green &Show on &endSUP &tld &Location cyto &Type rna &Color yellow &Show off &endtld &TLD &Location membrane &Type protein &Color yellow &Show off &endTLD &TKV &Location membrane &Type protein &Color white &Show on &endTKV &SUD //Sup and Dpp &Location membrane &Type complex &Color magenta &Show on &endSUD &SD //Sog and Dpp &Location membrane &Type complex &Color magenta &Show on &endSD &SG //Sog and Tsg &Location membrane &Type complex &Color magenta &Show on &endSG &DT &Location membrane &Type complex &Color magenta &Show on &endDT &DG &Location membrane &Type complex &Color magenta &Show on &endDG &rac &Location cyto &Type rna &Color green &Show on &endrac &rho &Location cyto &Type rna &Color green &Show on &endrho &endGenes &Interactions &dpp &Txn1Aff X K_Xdpp nu_Xdpp H_dpp &DecayAff dpp H_dpp &enddpp &DPP &TlnAff dpp H_DPP &Dimerize_AAff DPP SUP r_SUD max_SUP &Dimerize_AAff DPP TSG r_DG max_TSG &Dimerize_AAff DPP SOG r_SD max_SOG &Dimerize_AAff DPP TKV r_DT max_TKV &CleavageB_ECAff SD TLD K_TLDSD nu_TLDSD C_SD &CleavageB_ECAff DG TLD K_TLDDG nu_TLDDG C_DG &LMxferEAff DPP LMxfer_DPP &LMxferIAff DPP LMxfer_DPP &MxferOutAff DPP Mxfer_DPP &MxferInAff DPP Mxfer_DPP &DecayAff DPP H_DPP &endDPP &sog &Txn1Aff Y K_Ysog nu_Ysog H_sog &DecayAff sog H_sog &endsog &SOG &TlnAff sog H_SOG &Dimerize_AAff SOG DPP r_SD max_DPP &Dimerize_AAff SOG TSG r_SG max_TSG &LMxferEAff SOG LMxfer_SOG &LMxferIAff SOG LMxfer_SOG &MxferOutAff SOG Mxfer_SOG &MxferInAff SOG Mxfer_SOG &DecayAff SOG H_SOG &endSOG &tsg &Txn1Aff Z K_Ztsg nu_Ztsg H_tsg &DecayAff tsg H_tsg &endtsg &TSG &TlnAff tsg H_TSG &Dimerize_AAff TSG SOG r_SG max_SOG &Dimerize_AAff TSG DPP r_DG max_DPP //has to be a lot of TSG to get DG &LMxferEAff TSG LMxfer_TSG &LMxferIAff TSG LMxfer_TSG &MxferOutAff TSG Mxfer_TSG &MxferInAff TSG Mxfer_TSG &DecayAff TSG H_TSG &endTSG &tld &Txn1Aff X K_Xtld nu_Xtld H_tld &DecayAff tld H_tld &endtld &TLD &TlnAff tld H_TLD &LMxferEAff TLD LMxfer_TLD &LMxferIAff TLD LMxfer_TLD &MxferOutAff TLD Mxfer_TLD &MxferInAff TLD Mxfer_TLD &DecayAff TLD H_TLD &endTLD &SUP &CleavageB_ECAff SG TLD K_TLDSG nu_TLDSG C_SG &Dimerize_AAff SUP DPP r_SUD max_DPP &LMxferEAff SUP LMxfer_SUP &LMxferIAff SUP LMxfer_SUP &MxferOutAff SUP Mxfer_SUP &MxferInAff SUP Mxfer_SUP &DecayAff SUP H_SUP &endSUP &TKV &Dimerize_AAff TKV DPP r_DT max_DPP &LMxferEAff TKV LMxfer_TKV &LMxferIAff TKV LMxfer_TKV &MxferOutAff TKV Mxfer_TKV &MxferInAff TKV Mxfer_TKV &endTKV &SUD &Dimerize_BAff SUP DPP r_SUD max_SUP &DecayAff SUD H_SUD &endSUD &SD &Dimerize_BAff DPP SOG r_SD max_SOG &CleavageA_ECAff SD TLD K_TLDSD nu_TLDSD C_SD &LMxferEAff SD LMxfer_SD &LMxferIAff SD LMxfer_SD &MxferOutAff SD Mxfer_SD &MxferInAff SD Mxfer_SD &DecayAff SD H_SD &endSD &DT &Dimerize_BAff TKV DPP r_DT max_TKV &LMxferEAff DT LMxfer_DT &LMxferIAff DT LMxfer_DT &MxferOutAff DT Mxfer_DT &MxferInAff DT Mxfer_DT &DecayAff DT H_DT &endDT &DG &Dimerize_BAff DPP TSG r_DG max_TSG &CleavageA_ECAff DG TLD K_TLDDG nu_TLDDG C_DG &LMxferEAff DG LMxfer_DG &LMxferIAff DG LMxfer_DG &MxferOutAff DG Mxfer_DG &MxferInAff DG Mxfer_DG &DecayAff DG H_DG &endDG &SG &CleavageA_ECAff SG TLD K_TLDSG nu_TLDSG C_SG // think about recycling TSG from cleavage of SG &Dimerize_BAff SOG TSG r_SG max_TSG &LMxferEAff SG LMxfer_SG &LMxferIAff SG LMxfer_SG &MxferOutAff SG Mxfer_SG &MxferInAff SG Mxfer_SG &DecayAff SG H_SG &endSG &rho &Txn1Aff DT K_DTrho nu_DTrho H_rho &DecayAff rho H_rho &endrho &rac &Txn1Aff DT K_DTrac nu_DTrac H_rac &DecayAff rac H_rac &endrac &endInteractions &ParameterValues &H_dpp 20.0 1.0 100.0 Linear &H_DPP 20.0 1.0 100.0 Linear &H_sog 20.0 1.0 100.0 Linear &H_SOG 20.0 1.0 100.0 Linear &H_tsg 20.0 1.0 100.0 Linear &H_TSG 20.0 1.0 100.0 Linear &H_tld 20.0 1.0 100.0 Linear &H_TLD 20.0 1.0 100.0 Linear &H_SUP 20.0 1.0 100.0 Linear &H_SD 20.0 1.0 100.0 Linear &H_DG 20.0 1.0 100.0 Linear &H_SG 20.0 1.0 100.0 Linear &H_SUD 20.0 1.0 100.0 Linear &H_DT 20.0 1.0 100.0 Linear &H_rho 20.0 1.0 100.0 Linear &H_rac 20.0 1.0 100.0 Linear &K_Xdpp 0.01 0.001 1.0 Logarithmic &K_Ysog 0.01 0.001 1.0 Logarithmic &K_Xtld 0.01 0.001 1.0 Logarithmic &K_Ztsg 0.01 0.001 1.0 Logarithmic &K_TLDSD 0.001 0.001 1.0 Logarithmic &K_TLDDG 0.001 0.001 1.0 Logarithmic &K_TLDSG 0.001 0.001 1.0 Logarithmic &K_DTrho 0.05 0.01 1.0 Logarithmic &K_DTrac 0.9 0.1 1.0 Logarithmic &nu_Xdpp 2.0 1.0 10.0 Linear &nu_Ysog 2.0 1.0 10.0 Linear &nu_Xtld 2.0 1.0 10.0 Linear &nu_Ztsg 2.0 1.0 10.0 Linear &nu_TLDSD 2.0 1.0 10.0 Linear &nu_TLDDG 2.0 1.0 10.0 Linear &nu_TLDSG 2.0 1.0 10.0 Linear &nu_DTrho 2.0 1.0 10.0 Linear &nu_DTrac 8.0 1.0 10.0 Linear &LMxfer_SOG 1 0.001 1.0 Logarithmic &LMxfer_TSG 1 0.001 1.0 Logarithmic &LMxfer_SUP 1 0.001 1.0 Logarithmic &LMxfer_DPP 1 0.001 1.0 Logarithmic &LMxfer_TLD 1 0.001 1.0 Logarithmic &LMxfer_SD 1 0.001 1.0 Logarithmic &LMxfer_DG 1 0.001 1.0 Logarithmic &LMxfer_SG 0.1 0.001 1.0 Logarithmic &LMxfer_TKV 1 0.001 1.0 Logarithmic &LMxfer_DT 1 0.001 1.0 Logarithmic &Mxfer_SOG 1 0.1 1.0 Logarithmic &Mxfer_TSG 1 0.1 1.0 Logarithmic &Mxfer_SUP 1 0.1 1.0 Logarithmic &Mxfer_DPP 1 0.1 1.0 Logarithmic &Mxfer_TLD 1 0.1 1.0 Logarithmic &Mxfer_SD 1 0.1 1.0 Logarithmic &Mxfer_DG 1 0.1 1.0 Logarithmic &Mxfer_SG 0.1 0.1 1.0 Logarithmic &Mxfer_TKV 1 0.1 1.0 Logarithmic &Mxfer_DT 1 0.1 1.0 Logarithmic &r_SD 1.0E-3 1.0E-5 0.0010 Logarithmic &r_SUD 1.0E-3 1.0E-5 0.0010 Logarithmic &r_DT 1.0E-4 1.0E-5 0.0010 Logarithmic &r_DG 1.0E-3 1.0E-5 0.0010 Logarithmic &r_SG 1.0E-3 1.0E-5 0.0010 Logarithmic &max_DPP 1000.0 1000.0 1000000.0 Logarithmic &max_SOG 1000.0 1000.0 1000000.0 Logarithmic &max_TSG 1000.0 1000.0 1000000.0 Logarithmic &max_SUP 1000.0 1000.0 1000000.0 Logarithmic &max_TKV 100000.0 1000.0 1000000.0 Logarithmic &C_SD 0.1 0.01 1.0 Logarithmic &C_DG 0.1 0.01 1.0 Logarithmic &C_SG 0.1 0.01 1.0 Logarithmic &endParameterValues &InitLevels &BackgroundLevel X 0.0 &BackgroundLevel Y 0.0 &BackgroundLevel Z 0.0 &BackgroundLevel sog 0.0 &BackgroundLevel SOG 0.0 &BackgroundLevel tld 0.0 &BackgroundLevel TLD 0.0 &BackgroundLevel tsg 0.0 &BackgroundLevel TSG 0.0 &BackgroundLevel dpp 0.0 &BackgroundLevel DPP 0.0 &BackgroundLevel SUP 0.0 &BackgroundLevel TKV 1.0 &BackgroundLevel SUD 0.0 &BackgroundLevel SD 0.0 &BackgroundLevel SG 0.0 &BackgroundLevel DG 0.0 &BackgroundLevel DT 0.0 &BackgroundLevel rho 0.0 &BackgroundLevel rac 0.0 &CellIC &Node X &Value 1.0 &XPos 0 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 1 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 2 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 3 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 4 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 5 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 6 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 7 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 8 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 2 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 3 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 4 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 5 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 6 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 7 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 8 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 9 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 10 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 11 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 12 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 13 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 14 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 21 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 22 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 23 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 24 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 25 &YPos 0 &endIC &CellIC &Node Y &Value 1.0 &XPos 26 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 27 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 28 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 29 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 30 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 31 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 32 &YPos 0 &endIC &CellIC &Node Z &Value 1.0 &XPos 33 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 27 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 28 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 29 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 30 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 31 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 32 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 33 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 34 &YPos 0 &endIC &CellIC &Node X &Value 1.0 &XPos 35 &YPos 0 &endIC &endInitLevels &endNetwork